Novak Djokovic, Rafael Nadal and Carlos Alcaraz are all on the same half of the draw at the French Open, while women's world number one Iga Swiatek will face a qualifier in the first round at Roland Garros.
Djokovic, who will make his Grand Slam return having missed the Australian Open, opens in Paris against Yoshihito Nishioka, while record 21-time grand slam winner Nadal meets Australia's Jordan Thompson.
The veteran pair of Djokovic and Nadal could challenge each other in the quarter-finals in the top half of the draw, where Alcaraz could come across world number three Alexander Zverev.
Alcaraz faces a qualifier in the first round and has won 16 of his last 17 matches, with the one blemish on his remarkable run coming against Sebastian Korda, who the Spaniard could meet in the third round.
Daniil Medvedev will have to get past Argentine Facundo Bagnis in the first round, while Lorenzo Musetti stands in the way of last year's runner-up Stefanos Tsitsipas.
Medvedev and Tsitsipas are joined in the wide-open bottom half of the draw by Casper Ruud and Andrey Rublev, who meet home favourite Jo-Wilfried Tsonga and South Korea's Soonwoo Kwon respectively.
In the women's draw, 2020 champion Swiatek comes in as favourite and will look to continue her 28-match winning streak when she faces a qualifier in the first round, as does US Open winner Emma Raducanu.
The Brit will then take on Aliaksandra Sasnovich or Wang Xinyu before a potential last-16 meeting with Ons Jabeur, who first has to get past Poland's Magda Linette.
Meanwhile, Karolina Pliskova – who has a first-round clash with France's Tessah Andrianjafitrimo – could set up a quarter-final meeting with Swiatek, but the Pole may have to get past Simona Halep in the fourth round first.
Defending champion Barbora Krejcikova starts against Diane Parry, while Naomi Osaka was drawn against the in-form Amanda Anisimova, who beat the Japanese in the third round of the Australian Open.