Andy Murray's US Open campaign ended with a second-round loss to Felix Auger-Aliassime.
Last year's US Open runner-up, Daniil Medvedev was in fine form in New York.
After advancing to the second round, Serena Williams discussed Andy Murray's incredible win at Flushing Meadows.
Amid precautions due to COVID-19, Andy Murray still had an ice bath available at the US Open.
Yoshihito Nishioka held a two-set lead at Flushing Meadows, but Andy Murray fought back to seal a 4-6 4-6 7-6 (7-5) 7-6 (7-4) 6-4 triumph.
Andy Murray will return to grand slam action for the first time since a tearful 2019 Australian Open when he takes on Yoshihito Nishioka.
Rafael Nadal and Roger Federer are not playing the US Open, ahead of which it emerged Novak Djokovic is pushing plans for a players' union.
Top seed Novak Djokovic charged through on Tuesday, while Andy Murray lost to Milos Raonic in the last 16.
Dealing with a neck injury, Novak Djokovic reached the Western & Southern Open third round.
Andy Murray recorded his first win over a top-10 player since 2017, upsetting Alexander Zverev.