Nicolo Zaniolo's worst fears have been realised after it was confirmed he suffered a serious knee injury playing for Italy on Monday.
Giorgio Chiellini returned to action for Italy in a 1-0 win over the Netherlands, his display impressing Roberto Mancini.
Italy beat the Netherlands 1-0 in Amsterdam to go top of their Nations League group, much to Virgil van Dijk's frustration.
Dwight Lodeweges praised Italy for their performance against his Netherlands side in the Nations League.
Italy's medical staff - and Nicolo Zaniolo himself - are concerned about a new knee injury sustained in the win over the Netherlands.
Italy saw off the Netherlands 1-0 in Amsterdam to go top of their Nations League group, with Nicolo Barella getting the goal.
Italy were held to a 1-1 draw by Bosnia-Herzegovina and Roberto Mancini said changes in personnel would follow in their next game.
Edin Dzeko gave Bosnia-Herzegovina the lead against Italy only for Stefano Sensi to earn his side a point.
Roberto Mancini took on the Italy job two years ago and has his eyes on Euros and World Cup success, rather than a return to club football.
Mohamed Ihattaren and Perr Schuurs are among the new faces in the Netherlands squad, while Tim Krul and Leroy Fer are recalled.