Ben Youngs and Jamie George will achieve milestones for England in Saturday's Six Nations tussle with Italy in Rome.
Mario Balotelli was offloaded by Brescia at the end of last season, and there is no longer a queue of takers for the former Italy striker.
Willi Heinz will play no part in England's bid to win the Six Nations title in Rome, so Alex Mitchell comes into the squad.
England will be without some familiar faces for the Six Nations clash with Italy, with Eddie Jones including nine uncapped players.
Ireland will face France next weekend knowing they will win the title if they secure another bonus-point victory after hammering Italy.
The Six Nations resumes in Dublin on Saturday, with Ireland still in the hunt for the title ahead of their clash with Italy.
Marcello Lippi, 72, will not be returning to the dugout, having resigned as China head coach in November last year.
After seeing the Netherlands train like "young hyenas", Frank de Boer felt they were ready for a tactical change against Italy.
Poland took full advantage of Italy and the Netherlands drawing in Bergamo, moving top of the group by beating Bosnia-Herzegovina.
Poor finishing meant Italy were held to a 0-0 draw by Poland on Sunday, much to the frustration of Roberto Mancini.