Federico Bernardeschi and Riccardo Orsolini added to Vincenzo Grifo's brace as Italy registered a routine victory over Estonia in Florence.
A host of players could make their senior international bows this week. Here are six of the biggest stars preparing for those appearances.
Cesare Prandelli returns as Fiorentina head coach, with La Viola simultaneously announcing Giuseppe Iachini's sacking.
With Angelo Ogbonna and Alessio Romagnoli picking up injuries, Roberto Mancini has added three more players to Italy's latest squad.
Four of Pietro Pellegri's 10 appearances for Monaco have come this season and it has been enough to earn an Italy recall.
Roberto Mancini has tested positive for coronavirus ahead of Italy's upcoming triple-header of games and is self-isolating at home.
England secured the bonus-point win they needed to ramp up the pressure on Ireland and France in the battle for the Six Nations title.
Ben Youngs, who scored two tries for England against Italy on his 100th appearance, is already looking ahead to a bright future.
England, Ireland and France all head into the final round of Six Nations matches in contention to be crowned champions.
Ben Youngs and Jamie George will win their 100th and 50th caps respectively when England take on Italy in their final Six Nations game.