Jusuf Nurkic missed the majority of last season with a broken leg and the Portland Trail Blazers center has now sustained a fractured wrist.
Nikola Jokic and Stephen Curry were in good form as the Denver Nuggets beat the Golden State Warriors.
Philadelphia 76ers star Joel Embiid put up 45 points and 16 rebounds in a devastating display on Tuesday.
Charlotte Hornets rookie LaMelo Ball was at it again, while Giannis Antetokounmpo returned to the floor following a minor back injury.
LaMelo Ball announced his arrival in the NBA with a triple-double off the bench in the Charlotte Hornets' win over the Atlanta Hawks.
In a rematch of last season's Eastern Conference finals, the Boston Celtics overcame the Miami Heat.
The Philadelphia 76ers remain top in the East while Malcolm Brogdon dropped a clutch OT winner to keep the Indiana Pacers in the race.
Ben Simmons recorded his 29th career triple-double as the Philadelphia 76ers beat the Charlotte Hornets to go clear on top of the East.
Making his debut for the team, John Wall helped the Houston Rockets to a first win of the NBA season.
The Milwaukee Bucks were red-hot from three-point range as the Orlando Magic improved to 4-0 on Tuesday.