Andrew Redmayne, Brandon O'Neill, Lawrence Thomas, Harry Souttar, Ryan Williams and Brandon Borrello are in line to earn their first caps.
Bahrain stand between South Korea and a place in the 2019 Asian Cup quarter-finals, but Paulo Bento is feeling bullish despite pressure.
Newcastle United midfielder Ki Sung-yueng will play no further part in the Asian Cup after a hamstring injury ruled him out.
Son Heung-min impressed on his first outing of the 2019 Asian Cup as South Korea comfortably defeated China to top Group C.
Both sides are already through to the last 16 of the Asian Cup, but top spot in Group C is up for grabs at Al Nahyan Stadium on Wednesday.
Despite hitting the crossbar three times, South Korea just about did enough to beat Kyrgyzstan and book their passage in the 2019 Asian Cup.
Following a narrow win over Philippines, Paulo Bento has urged South Korea to press on against Kyrgyzstan.
South Korea got their 2019 Asian Cup campaign off to a winning - if underwhelming - start, beating Philippines 1-0 in Group C.
Australia welcome back two of their stars for a friendly against South Korea later this month.
Having secured exemption from military service by captaining South Korea to Asian Games glory, Son Heung-min confessed he was nervous.