Arsenal host Tottenham and Manchester United are at home to David Moyes' West Ham in a bumper round of Premier League action.
Manchester City's remarkable winning run was ended by their local rivals, before Harry Kane and Son Heung-min set a Premier League record.
Manchester United will attempt to halt the Manchester City juggernaut as they look to knock their neighbours off course.
Newcastle v Wolves is not a fixture enjoyed by goalkeepers, while Pep Guardiola racked up another impressive landmark with Manchester City.
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Manchester United are 10 points behind Manchester City but will remain focused on being "the best possible Man United every single game".
Ole Gunnar Solskjaer berkata Manchester United akan memberikan tumpuan kepada prestasi sendiri bagi apa-apa kejutan dalam saingan Liga Perdana Inggeris (EPL).
The top three in the Premier League all won and David Moyes' West Ham climbed to fourth after their own precious victory.
Manchester United were slow to get started three days on from their trip to Turin but had enough to see off Newcastle United.
Manchester United will still take on Newcastle United on Sunday despite members of Ole Gunnar Solskjaer's staff having to self-isolate.