Harry Kane faces a race to be fit for Euro 2020, and Liverpool's Jurgen Klopp pointed to the demands on players as he called for FA action.
Six of the Premier League's top scorers this season are English and, ahead of Euro 2020, will 2019-20 be a springboard for homegrown talent?
Harry Kane has a serious hamstring injury and Jose Mourinho was unable to give a timescale for his return ahead of facing Middlesbrough.
Tammy Abraham must view Harry Kane's injury as a chance to establish himself in England's line-up, says Chelsea boss Frank Lampard.
Ben Davies and Hugo Lloris have played just once between them under Jose Mourinho, but they are close to returning to the team.
With Harry Kane out until April, Jose Mourinho is hopeful Daniel Levy can come up with the "right solutions" in the transfer market.
We use Opta data to assess how Tottenham and England fare without injured striker Harry Kane, who is facing a lengthy lay-off.
Tottenham and England are each set to suffer without Harry Kane, giving Jose Mourinho and Gareth Southgate some big decisions to make.
Harry Kane will be out of action until April at the earliest, with the Tottenham and England striker set to undergo hamstring surgery.
Tottenham are without a win in two Premier League games as they prepare to take on Jurgen Klopp's unbeaten table-toppers Liverpool.