Dawid Malan managed 30 runs off his final 10 deliveries at the crease, helping England earn a four-wicket win in Paarl.
Owen Farrell booted 14 points and could afford to miss a couple of kicks as Eddie Jones' England won comfortably enough in Wales.
England chased down 180 to defeat South Africa at Newlands as they started their tour on a high.
South Africa and England get what promises to be a thrilling Twenty20 International series under way at Newlands on Friday.
Owen Farrell moves to centre as George Ford returns to the England side, while Alun Wyn Jones is back in the Wales starting line-up
Diego Maradona and Peter Shilton never met to make their peace after the Hand of God goal in Argentina's 1986 World Cup win over England.
Peter Reid came up against Diego Maradona, infamously at the 1986 World Cup, and he recalled the Argentina great's career.
Jonathan Joseph or Owen Farrell could move into midfield against Wales after Ollie Lawrence was omitted from the England squad.
Struggling Wales will be without Ross Moriarty when they face Six Nations champions England this weekend.
Jacob Umaga and George Furbank have withdrawn, but Anthony Watson and Luke Cowan-Dickie are back in the England squad.