Joe Marler opted out of the Six Nations in order to be with his family and Eddie Jones says he can still have an international future.
A day after losing Joe Launchbury and Joe Marler for the Six Nations, England have revealed Sam Underhill will also miss the tournament.
Eddie Jones has included three uncapped players for his England squad for the Six Nations, which starts in February.
Rhys Webb was a notable absentee from Wales' Six Nations squad, but Dan Lydiate returns and the uncapped Josh Macleod has been included.
England's Six Nations preparations have been impacted by a positive coronavirus test for assistant coach Matt Proudfoot.
England open their Six Nations campaign against Scotland on February 6 - but Kyle Sinckler will not be available.
Less than a month before the Six Nations is due to start, Bernard Laporte is in no doubt that the competition will go ahead.
Alun Wyn Jones, the most capped Test player of all time, expects to captain Wales in their first match of the Six Nations in Cardiff.
Wales could be without captain Alun Wyn Jones for their Six Nations opener against Ireland as he recovers from a knee injury.
One of rugby's most prominent referees Nigel Owens has spoken of his bulimia struggle in a television programme on male eating disorders.