A 10th goal in his last 10 Premier League starts from Danny Ings handed Southampton a dose of revenge over Leicester City.
Marcus Rashford and Juan Mata led the way for Manchester United as they thrashed Norwich City 4-0 at Old Trafford on Saturday.
Manchester United were dominated by rivals City in a sobering EFL Cup loss, but Marcus Rashford has not given up hope of a turnaround.
Bernardo Silva inspired Manchester City to an emphatic win over Manchester United, putting them on course for another EFL Cup final.
Arsenal won for the second time in 13 Premier League games after Nicolas Pepe and Sokratis scored against Manchester United.
Anthony Martial scored in the 44th minute against Burnley but Manchester United faced some nervous moments before winning 2-0 at Turf Moor.
Manchester United kept their first clean sheet in 15 Premier League matches as they beat Burnley 2-0 at Turf Moor.
Manchester United manager Ole Gunnar Solskjaer compared Marcus Rashford to Cristiano Ronaldo again.
Newcastle United held an early lead at OId Trafford but were soundly beaten in the end, going down 4-1 to Manchester United.
Marcus Rashford is a long way from reaching his potential, according to Manchester United team-mate Nemanja Matic.