There was no catching George Russell as he won by almost 40 seconds, while Pierre-Emerick Aubameyang finished back in 16th.
Milan, Ayrton Senna and Wilfred Benitez all had cause for celebration on May 23 in the past.
For the first time in 66 years, there will be no Monaco Grand Prix in the Formula One season, with the event having been cancelled.
The proliferation of COVID-19 has led to the FIA calling off scheduled races in the Netherlands, Spain and Monaco.
Lewis Hamilton might be dominant, but there has been no shortage of incident in F1 this year.
Lewis Hamilton held off Max Verstappen to win the Monaco Grand Prix and the Red Bull driver felt it was impossible to overtake.
In the first race since Niki Lauda's death, Lewis Hamilton said he raced with the spirit of the three-time Formula One champion.
Contact between Max Verstappen and Valtteri Bottas cost Mercedes a one-two, but Lewis Hamilton fought for victory in Monaco.
Nothing is ever certain in Formula One, but Lewis Hamilton and Mercedes are very well placed to make history at the Monaco Grand Prix.
Kevin Magnussen is up to fifth on the grid for the Monaco Grand Prix after Pierre Gasly was penalised for impeding Romain Grosjean.