Neymar notched a goal and an assist in his first match since June, much to the delight of Brazil team-mate Dani Alves.
Making his first appearance of the season, Neymar scored and set up Casemiro's opener in Miami on Friday.
Jonathan Rodriguez came off the bench and netted a last-gasp winner for visiting Uruguay against Costa Rica.
Erick Gutierrez and Uriel Antuna added to Javier Hernandez's first-half header as Mexico eased past the United States on Friday.
In a rematch of the Copa America third-place play-off, Argentina and Chile drew in a friendly.
The Madagascar Football Association has withdrawn its national team from a planned friendly on Saturday against South Africa.
Argentina named seven uncapped players for their friendlies against Chile and Mexico next month.
Real Madrid's pre-season finished with a penalty shoot-out defeat to Roma after a 2-2 draw in which Gareth Bale returned to action.
Gareth Bale made the trip to Rome as he prepared to play for Real Madrid for the first time since a move to China fell through.