England secured the bonus-point win they needed to ramp up the pressure on Ireland and France in the battle for the Six Nations title.
Ben Youngs, who scored two tries for England against Italy on his 100th appearance, is already looking ahead to a bright future.
Alun Wyn Jones made his 149th Test appearance on Saturday, though could not inspire Wales to a Six Nations win over Scotland.
Wales slumped to a first Six Nations home defeat to Scotland since 2002 on a disappointing big day for captain Alun Wyn Jones.
New Zealand hammered Australia by a record margin to retain the Bledisloe Cup and captain Sam Cane warned there is more to come.
A dominant display from New Zealand ensured another Bledisloe Cup triumph for the All Blacks, with Australia humbled on home soil.
Wales captain Alun Wyn Jones will make a world record 149th international appearance when he leads his country against Scotland.
England, Ireland and France all head into the final round of Six Nations matches in contention to be crowned champions.
New Zealand can clinch the Bledisloe Cup with a win on Saturday, but the trophy pursuit could yet go down to a fourth game in Brisbane.
The Rugby Football Union has charged 13 Barbarians players for breaching COVID-19 protocols which meant a match with England was cancelled.