France beat Wales 32-30 through a last-gasp Brice Dulin try on Saturday to ensure that the Six Nations will go down to the final game.
France scored two late tries to deny Wales the Grand Slam and keep their hopes of winning the Six Nations alive in Paris.
Ireland wrapped up their Six Nations campaign with a comfortable win over England in Dublin, much to the delight of skipper Johnny Sexton.
Ireland completed their 2021 Six Nations campaign with a third win in a row, seeing off England 32-18 at the Aviva Stadium.
Italy opened the scoring but it was then one-way traffic as eight-try Scotland crushed the Azzurri, delighting home captain Stuart Hogg.
Italy scored first but Scotland then took firm control of their Six Nations clash in Edinburgh, scoring eight tries against their visitors.
The Chiefs trailed 26-7 at half-time but scored four second-half tries to get past the Hurricanes 35-29.
The Waratahs left their rally far too late in a fourth straight defeat on Friday, losing to a Rebels team inspired by Matt Toomua.
Wales need a win in Paris to complete a Grand Slam and seal their second Six Nations title in the space of three years.
Fabien Galthie's France retain Six Nations title hopes and have learned the date of their final match against Scotland.