Ben Youngs and Jamie George will achieve milestones for England in Saturday's Six Nations tussle with Italy in Rome.
Richie McCaw's 148 Test caps will be surpassed by Alun Wyn Jones when Wales take on Scotland in Llanelli on Saturday.
Sam Whitelock is back for the All Blacks ahead of Saturday's clash against the Wallabies.
Willi Heinz will play no part in England's bid to win the Six Nations title in Rome, so Alex Mitchell comes into the squad.
Ireland bring in Robbie Henshaw for injured centre Garry Ringrose ahead of their decisive Six Nations clash with France this weekend.
England will be without some familiar faces for the Six Nations clash with Italy, with Eddie Jones including nine uncapped players.
Scrum-half John Cooney was left out Ireland's squad to face Italy but will provide cover for the clash with France on the final weekend.
Garry Ringrose is facing another spell on the sidelines after breaking his jaw early in Ireland's thumping Six Nations win over Italy.
Antoine Dupont scored two tries as France denied Wales victory on Alun Wyn Jones' record-equalling 148th international appearance.
Henry Slade's try and some fine kicking from Joe Simmonds earned Exeter Chiefs a hard-fought 19-13 win over Wasps in the Premiership final.