Rodriguinho's seventh-minute opener and Jadson's last-gasp strike saw Cruzeiro account for Deportivo Lara in Group B on Wednesday.
Cruzeiro edged Huracan in wet conditions, while Deportivo Lara's clash against Emelec had to be rescheduled due to a floodlight issue.
We assess the leading candidates for glory and the potential stars ahead of the start of the 2019 Copa Libertadores.
Although he has enjoyed his time back at Cruzeiro, Lucas Silva has not given up on forging a career with Real Madrid.
Boca Juniors advanced 3-1 on aggregate following their second-leg stalemate away to Cruzeiro in Belo Horizonte.
Cruzeiro will not have to play the second leg of their Copa Libertadores quarter-final against Boca Juniors without Dede.
Dede was dismissed against Boca Juniors after a VAR review and the CBF has written to CONMEBOL in support of Cruzeiro's appeal.
Dede was sent off for a collision with Esteban Andrada that fractured the Boca Juniors goalkeeper's jaw, but Mano Menezes was not happy.
Mauro Zarate and Pablo Perez helped Boca Juniors to a win over Cruzeiro in the Copa Libertadores.
River Plate were too good for Racing Club to move into the quarter-finals of the Copa Libertadores.