Belinda Bencic was the highest seed to be eliminated on Tuesday, though Garbine Muguruza had no such issues.
Sofia Kenin, Belinda Bencic and Elise Mertens were all beaten at the Volvo Car Open, where Ash Barty moved through.
Ash Barty and Victoria Azarenka both advanced on Saturday as Simona Halep succumbed to injury.
Iga Swiatek's first career title was her shock French Open victory in October, but now the Polish teenager has added another in Adelaide.
Iga Swiatek reached her first final since winning the French Open and will tackle Belinda Bencic after the Swiss edged out Coco Gauff.
Danielle Collins' injury allowed Iga Swiatek a straightforward progression in Adelaide, but Coco Gauff had to rally to remain alive.
Coco Gauff continued her impressive run in Adelaide, while home favourite Ash Barty suffered a surprise defeat.
Karolina Pliskova took out her frustrations during a third-round defeat, but Ash Barty was able to reach week two in Melbourne.
On another warm day in Melbourne, there were contrasting results for star duo Sofia Kenin and Ash Barty in the second round.
Garbine Muguruza and Sofia Kenin reached the second round, while Victoria Azarenka bowed out of the Australian Open.