Having reached the semi-finals of the competition last season, Ajax are safely through to the Champions League group stage.
APOEL almost claimed a Champions League play-off upset against Ajax after the Dutch side had a man sent off.
The giants fell in the third round of qualifying, with Porto and Celtic headlining a day of casualties.
Celtic will meet Slavia Prague if they reach the Champions League play-offs, Ajax perhaps have an easier draw, and Porto face a big test.
Oliver Glasner will take over at Bundesliga club Wolfsburg at the end of the season, replacing Bruno Labbadia.