There was final-day delight for Genoa in Serie A, as they remained in the top tier and Lecce went straight back down.
After a single season in Italy's top flight, Brescia will return to Serie B following a defeat at Lecce.
Patric will miss Lazio's potentially pivotal clash with Juventus after he was suspended following his red card against Lecce.
Miralem Pjanic's Juventus future remains unclear and Maurizio Sarri is none the wiser regarding reports he is to join Barcelona.
Maurizio Sarri discussed Cristiano Ronaldo following Juventus' 4-0 rout of 10-man Lecce on Friday.
Paulo Dybala, Cristiano Ronaldo dan Gonzalo Higuain membantu Juventus berkelebihan tujuh mata di puncak Serie A selepas mencatatkan kemenangan 4-0 ke atas Lecce, yang beraksi dengan 10 pemain, di Stadium Allianz awal pagi tadi.
It turned into a comfortable evening for Juventus, for who Paulo Dybala, Cristiano Ronaldo and Gonzalo Higuain were on target versus Lecce.
Juventus boss Maurizio Sarri provided a positive update on Gonzalo Higuain ahead of the game against struggling Lecce.
Pengurus Milan, Stefano Pioli, menolak spekulasi yang semakin meningkat bahawa dia akan digantikan oleh Ralf Rangnick pada penghujung musim ini setelah mengatasi Lecce 4-1.
Stefano Pioli was asked about rumours linking Ralf Rangnick with a move to Milan.