Asian Cup champions Qatar are the unusual challenge in front of Paraguay as Eduardo Berizzo plots their progress from a difficult group.
Paraguay could be without attacking midfielder Miguel Almiron for the Copa America after he sustained an injury in the Premier League.
Arsenal edged to a 10th Premier League home win in a row against Newcastle United, thanks to Aaron Ramsey and Alexandre Lacazette.
Mexico made it two wins from two under Gerardo Martino with an entertaining victory over Paraguay.
Even as his contract winds down and amid reported interest from Leicester City, Rafael Benitez is focused on Newcastle United.
Miguel Almiron played an inspirational role for Newcastle United versus Huddersfield Town and Rafael Benitez praised his performance.
Record signing Miguel Almiron was excellent for Newcastle United, as they easily beat Huddersfield Town 2-0 at St James' Park.
Newcastle United broke their transfer record for the first time since 2005 to sign Miguel Almiron, who is honoured by that show of faith.
Miguel Almiron has left MLS Cup champions for Newcastle United in a club-record deal.