Jofra Archer has been replaced by Sam Curran at the Rose Bowl, while Pakistan's Fawad Alam is making a first Test appearance since 2009.
Ben Stokes' absence leaves England light in the middle order and Pakistan are out take advantage.
England will play the final two Tests against Pakistan in Southampton without Ben Stokes, who is to fly to New Zealand.
England will face a testing run chase in the first Test against Pakistan, but Ben Stokes gave them fresh hope of pulling off an opening win.
Ben Stokes will again play as a specialist batsman in the first Test against a Pakistan side that includes two leg-spinners.
Unavailable for the second Test, which England won, Jofra Archer has been recalled to Joe Root's attack, alongside James Anderson.
England are determined not to over-work Ben Stokes, the man Joe Root says is always "desperate to win you the game".
England were toying on Thursday with their bowling options for the third Test against West Indies, reluctant to over-work Ben Stokes.
Ben Stokes' continued improvement has impressed team-mate James Anderson, who is glad to have him in England's team.
Ben Stokes is officially the best all-rounder in the world after playing a huge part in England's victory over West Indies.