Ireland will be without Garry Ringrose for their decisive Six Nations showdown with France after the centre was ruled out for up to six weeks with a broken jaw.
Ringrose was caught in the face by Edoardo Padovani's knee early in the 50-17 hammering of Italy when the Six Nations resumed at the Aviva Stadium on Saturday.
The Leinster player, who was replaced by Robbie Henshaw, will miss the trip to Paris for a final match of the tournament that Ireland will start needing another bonus-point win to secure the title.
Ireland head coach Andy Farrell said: "Garry Ringrose has broken his jaw, so bad news for us all.
"He's been so good for us the last 10 days, he has been absolutely fantastic with his leadership and he was a big part of the reason why we got what we wanted [versus Italy].
"He was unfortunate with his thumb injury earlier in the Six Nations and has come back and had a setback like that which will keep him out for four to six weeks, so we're gutted for Garry."
Ringrose also looks set to sit out the Autumn Nations Cup encounters with Wales, England and Georgia in November.
Ireland are a point ahead of France and England - who play Italy in Rome - ahead of the final round of Six Nations matches.