While Liverpool, Bayern Munich, Manchester City and Porto have already secured their place in the Champions League knockout stages, some big names are in danger of a shock elimination.
After making history by leading Real Madrid to three straight Champions League titles during his first stint as head coach, Zinedine Zidane is on the verge of another first that could well place his future at the club in serious jeopardy.
Inter are also fighting for their future in the competition, as are Atletico Madrid and semi-finalists from the past two campaigns Ajax and Atalanta.
Ahead of what is sure to be a thrilling finale to the group stage, we take a look at the best stats courtesy of Opta.
Midtjylland v Liverpool: A first in reach for Reds
Jurgen Klopp's men are already guaranteed to finish top of Group D but victory over bottom side Midtjylland will see them register five wins in a single Champions League group stage for the first time.
Their form on matchday six in the competition is strong too. They have triumphed in each of their past three final group stage matches by an aggregate score of 10-0.
Taking three points would see the Reds become just the third Premier League side, after Chelsea in 2003-04 and Manchester United in 2010-11, to win all three of their away games in the group stage.
Should Caoimhin Kelleher be given another opportunity between the posts, he could become the first Liverpool goalkeeper to keep a clean sheet in their first two Champions League starts.
Salzburg v Atletico Madrid: Shoot-out for progression
Atletico will be looking to avoid just a second exit at this stage in their eighth campaign in the competition under Diego Simeone.
They will need to be wary of Salzburg forward Mergim Berisha, who has scored four goals in as many Champions League starts for the club this season – only Erling Haaland (eight in 2019-20) has scored more for the Austrian side in a single campaign in Europe's premier club competition.
Enock Mwepu will be another threat for the visitors, having attempted six shots and created four chances in Salzburg's 3-1 win over Lokomotiv Moscow last time out.
Ahead of matchday six, only two players had been directly involved in more shots in a Champions League game this season – Lionel Messi and Munir El Haddad played a part in 11 against Ferencvaros and Krasnodar respectively.
Real Madrid v Borussia Monchengladbach: Blancos on the brink
A win will see Zidane's struggling Madrid into the knockout rounds and avoid the ignominy of suffering their first Champions League group stage exit after 28 consecutive progressions.
The drop-off this season can be seen in the fact their defeat to Shakhtar Donetsk last time out was Madrid's fourth in their past seven matches in the competition – they only lost five of their first 39 Champions League games under Zidane (W25 D9).
Goals should be expected at the Estadio Alfredo Di Stefano, with the previous five meetings between the teams seeing 20 goals scored with 10 apiece.
Gladbach just need to avoid defeat to advance and some game time for Alassane Plea would likely help them achieve that; he has been directly involved in eight goals (five scored, three assisted) in his five Champions League appearances at an average of one every 45 minutes.
Inter v Shakhtar Donetsk: Conte's San Siro woe
Failure to win against high-flying Shakhtar at San Siro will see Inter bow out at the group stage for a third consecutive season. Before this run, they had advanced from 11 of their 12 pool appearances (including the second group stage) in the competition.
Shakhtar may have beaten Madrid twice but they have a goal difference of minus seven; the only teams to have advanced with such a record after five games are Galatasaray in 2013-14 and Atalanta in 2019-20.
Inter will therefore be hoping Romelu Lukaku can help get them over the line. The Belgium striker has played a role in 17 goals in his 15 European matches for the Nerazzurri, including scoring a double in a 5-0 success over the Ukrainian side in last season's Europa League semi-final.
A strong performance from Lukaku would go a significant way to ensuring Antonio Conte does not become the first Inter coach to oversee a Champions League group stage campaign without a home win.
Ajax v Atalanta
2 - Ajax are unbeaten in their last seven games against Italian opponents in the Champions League, but five of these have ended in draws. They must win to reach the last 16.
4 - Atalanta went winless at home in the Champions League group stage this season (D2 L1), yet will qualify for the knockout rounds if they avoid defeat here. It will be just the fourth time a team has picked up as little as two points at home in a group stage and still qualified for the next round, after Roma in 2002-03 and Milan in both 2009-10 and 2012-13.
Bayern Munich v Lokomotiv Moscow
13 - Bayern drew 1-1 against Atletico in their most recent Champions League outing – the first time they failed to win in the competition under Hansi Flick after he oversaw 12 straight victories.
1 - Lokomotiv have drawn both of their away games in the Champions League this season and have never previously gone unbeaten away from home in a single season in the competition.
Manchester City v Marseille
16 – If City beat Marseille they will have accrued 16 points in the Champions League group stage this season, the joint-most of any English side in a single campaign along with Arsenal in 2005-06 (finalists), Manchester United in 2007-08 (winners), and Tottenham in 2017-18 (last 16).
8 - Marseille have lost each of their past seven away games in the Champions League and another defeat here would see them record their worst ever losing run on the road in the competition.
Olympiacos v Porto
100 - Olympiacos have won all three of their home Champions League matches against Porto, in three successive seasons between 1997 and 1999 – it is their best 100 per cent record on their own patch against any side in the competition.
4 - Porto have kept a clean sheet in four consecutive Champions League matches since conceding three goals away to Manchester City in October – the last side to record five or more consecutive shutouts in the competition was Juventus in 2016-17. Manchester City are also on a run of four.