Cristiano Ronaldo is chasing another slice of history when Juventus travel to Lokomotiv Moscow in the Champions League on Wednesday.
Tottenham, meanwhile, will hope Harry Kane can continue his wonderful form in the competition against Red Star Belgrade, while Manchester City take on Atalanta at San Siro.
Elsewhere, Kylian Mbappe will be licking his lips at the prospect of facing Club Brugge again after he plundered a hat-trick against them two weeks ago.
Here is the pick of the key Opta facts for Wednesday's eight matches.
Paris Saint-Germain v Club Brugge
4 - PSG forward Mbappe scored a hat-trick as a substitute against Brugge on matchday three, becoming only the fourth player to achieve the feat in the Champions League. In three games against Belgian opposition, Mbappe averages a goal or assist every 28 minutes.
2 - Emmanuel Dennis scored both of Brugge's goals in their previous Champions League away game against Real Madrid. No player has ever found the net in consecutive matches on the road for the Belgian side in the competition.
Real Madrid v Galatasaray
50 - Karim Benzema is just two Champions League goals short of his 50th for Madrid, with only Lionel Messi (113 for Barcelona), Cristiano Ronaldo (105 for Madrid) and Raul (66 for Madrid) reaching the milestone for a single side. However, Benzema is without a goal in his past four matches in the competition, despite attempting 16 shots across those games.
5 - Galatasaray have failed to score in their past five away Champions League matches, despite attempting 45 shots in that timeframe. The last team to fail to score in six away games in a row were Schalke in November 2010.
Bayern Munich v Olympiacos
13 - Bayern have scored 13 goals after just three Champions League games this season. The only team with more after three games are Arsenal in 2010-11 (14 goals).
10 - Olympiacos have managed just 10 shots on target across their opening three Champions League matches this term – one fewer than Bayern striker Robert Lewandowski has attempted.
Red Star Belgrade v Tottenham
6 - Red Star's Marko Marin made six chances in their 5-0 defeat against Spurs on matchday three. No player has created more in the Champions League this season (13, level with Toni Kroos).
18 - Spurs striker Kane has scored 18 goals in just 22 Champions League appearances, including four in three appearances this season. In the history of the competition, the fewest number of matches needed to reach 20 goals is 26, set by Alessandro Del Piero in April 1998.
Atalanta v Manchester City
11 - Atalanta have conceded more Champions League goals than any other team this season (11). Only two teams have conceded more in their first three Champions League games – Slavia Prague (12) and Helsingborgs (13).
5 - Sergio Aguero has found the net in each of his past five away Champions League group stage matches for City (five goals), a run stretching back to September 2017.
Dinamo Zagreb v Shakhtar Donetsk
45 - Dinamo's Mislav Orsic is averaging a goal or assist every 45 minutes in the Champions League this season, scoring four and assisting one in just 227 minutes of action. Should Orsic notch in this game, he would have reached five goals in just four appearances, with only Erling Haaland and Didier Drogba having done so in fewer games (three).
22 - Shakhtar goalkeeper Andriy Pyatov has not kept a clean sheet in any of his past 22 Champions League starts. The last goalkeeper to go on a longer such run in the competition was Igor Akinfeev (43) between November 2006 and October 2017.
Bayer Leverkusen v Atletico Madrid
3 - Leverkusen are one of two clubs to lose their three Champions League games this season, along with Atalanta. They are the first German side to lose their opening three group stage matches since Stuttgart in 2007-08.
3 - Atletico have won three Champions League games against Bayer Leverkusen; they have only won more against PSV (four).
Lokomotiv Moscow v Juventus
9 - Lokomotiv striker Eder has been on the losing side in his each of his past nine Champions League starts, dating back to October 2012 for Braga. The last player to lose on 10 consecutive starts in the competition was Junior Fernandes (11) for Dinamo Zagreb, a run that ended in December 2016.
33 - Ronaldo had eight shots without scoring in Juve's 2-1 win over Lokomotiv on matchday three. Should he score in this match, he would break the record for opponents scored against in the Champions League, with Ronaldo currently level on 33 with Raul and Messi.