Ante Rebic has been passed fit to partner Rafael Leao up front but it remains to be seen if Alessio Romagnoli will start when injury-hit Milan face Udinese in Serie A on Wednesday.
Rebic scored the winner in the Rossoneri's 2-1 victory over Roma on Sunday before being withdrawn due to injury.
Milan head coach Pioli says the Croatia international will be ready to start against Udinese and Leao will take his place in the team after coming off the bench at the weekend to replace Zlatan Ibrahimovic.
Asked about Rebic's fitness, Pioli said: "He's fine, he can start against Udinese. On Sunday he played a great match, his characteristics are important for us. There is no doubt about his qualities."
Pioli said following the much-needed win over Roma that he suspected Ibrahimovic, who is appearing at the Sanremo music festival, was weary rather than wounded and the talismanic striker will not face Luca Gotti's men.
Milan are taking no risks over Ibrahimovic's fitness, with a Europa League showdown against his former club Manchester United to come next week.
Hakan Calhanoglu will also miss the encounter with Udinese, which second-placed Milan will start knowing a victory would leave them just a point behind leaders Inter, while Ismael Bennacer and Mario Mandzukic are expected to return next week.
Leao has not scored since January 9, but Pioli has full faith in the 21-year-old.
"Up until a few days ago we talked about an improved Leao and inside the game," he said. "I'm satisfied with Leao, tomorrow he will start from the beginning.
"From a mental point of view he is ready, he has grown a lot."
Captain Romagnoli was left out of the starting line-up at Stadio Olimpico and Pioli refused to be drawn on whether the defender will be restored to the side.
"The matches are all important but also different, for me to be able to choose is great luck," Pioli said. "Only tomorrow morning we will try the starting eleven, we will choose the most suitable team and the best players."