Anthony Martial and Luke Shaw have come into the Manchester United team for a crunch derby against Manchester City at Etihad Stadium.
Forward Martial takes the place of young striker Mason Greenwood, while Shaw steps in at left-back for Ashley Young.
Both Greenwood and Young were named as substitutes by manager Ole Gunnar Solskjaer.
It means United will start with Martial in attack along with Marcus Rashford, who scored both his side's goals in the 2-1 win over Tottenham on Wednesday, and Daniel James.
With captain Young out of the starting XI, Harry Maguire takes the armband for the visitors.
City boss Pep Guardiola has made a single alteration to the side that trounced Burnley 4-1 on Tuesday, as England defender John Stones replaces Nicolas Otamendi, who begins on the bench.
United sit eighth in the Premier League and are in desperate need of following one strong performance with another, to show they can produce consistently under Solskjaer's much-scrutinised leadership.
Reigning champions City, meanwhile, begin the game a distant 14 points adrift of leaders Liverpool, who were resounding 3-0 winners at Bournemouth earlier on Saturday.