Leeds United beat Reading 1-0 at Elland Road to move five points clear of the chasing pack in the race for automatic promotion from the Championship.
Third-placed Fulham were held 1-1 by Derby County on Friday and Brentford in fourth played out a 2-2 draw with Blackburn Rovers.
Nottingham Forest and Bristol City also dropped points, drawing 0-0 with QPR and losing 3-0 to leaders West Brom respectively, with the Baggies maintaining their four-point gap on Leeds.
Elsewhere, Wigan Athletic and Barnsley picked up wins to boost their survival hopes.
LEEDS, WEST BROM PULLING AWAY
Pablo Hernandez's 57th-minute strike earned Leeds back-to-back 1-0 home wins.
West Brom appear over their mid-season wobble after making it four wins in five matches with a comfortable victory.
Callum Robinson put Slaven Bilic's side on course for an 11th away win of the campaign with a fortuitous opener and Hal Robson-Kanu netted twice, either side of Romaine Sawyers' straight red for grabbing Jamie Paterson by the throat.
CHASING PACK FALTER
Brentford fought from two goals down to draw 2-2 with Blackburn as they joined west London rivals Fulham in dropping points.
Ollie Watkins scored an impressive volley and Said Benrahma netted from the penalty spot to cancel out Adam Armstrong's double.
Forest missed out on the chance to move up to third after failing to break down QPR in a stalemate at City Ground, while Preston North End recovered from a goal down to beat Hull City 2-1.
HOPE FOR WIGAN, BARNSLEY
Shaun Hutchinson's own goal was enough for Wigan to earn just an eighth league win of the campaign at home to Millwall, while Barnsley built on their shock 3-0 win at Fulham last weekend with a 1-0 victory over Middlesbrough.
Wigan and Barnsley are now two and five points adrift of 21st-placed Huddersfield respectively following the Terriers' 3-1 defeat at Swansea City.
Luton Town are now occupying bottom place, with Lyle Taylor's double earning Charlton Athletic a 3-1 win.
Elsewhere, a Callum Paterson own goal and a scrambled finish from Joe Allen saw Stoke City earn a 2-0 home win against Cardiff City that leaves them three points clear of the drop-zone.
SIX-GOAL THRILLER AT ST ANDREW'S
Birmingham City and Sheffield Wednesday remain locked on 45 points following a 3-3 draw.
Garry Monk was denied a winning return to one of his former clubs by Scott Hogan's equaliser in added time, the Aston Villa loanee's fourth goal in five matches.
Wednesday had twice battled back from a goal down before Jacob Murphy put them in front, but they are now winless in six outings.