Dele Alli's return to Tottenham's starting line-up lasted just 45 minutes as Jose Mourinho made four half-time changes at Royal Antwerp on Thursday.
Alli had been restored to the first XI for the first time in over a month but was among a quartet of players to make way after a dismal first half in the Europa League group-stage clash.
Giovani Lo Celso, Steven Bergwijn and Carlos Vinicius were all also substituted, with Pierre-Emile Hojbjerg, Erik Lamela, Lucas Moura and Son Heung-min introduced.
Gareth Bale made way before the hour-mark with no immediate improvement in attack as Harry Kane was called for.
Spurs trailed 1-0 to Antwerp after Lior Refaelov's first-half strike following an error at the back from Ben Davies.
46 - Coco comes on.
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Tottenham had offered precious little going the other way, mustering seven shots – all from outside the box.
Alli, who is yet to play more than an hour in a match this season, completed an underwhelming 74.2 per cent of his passes and won neither of his duels while failing to register a tackle, clearance or interception.
The England midfielder created one of the seven speculative efforts in attack.
Bale had two attempts but failed to hit the target and did not create a single chance.