Arsenal were dealt a blow by Granit Xhaka's dreadful mistake against Burnley, while Southampton ended a nine-match Premier League winless streak on Saturday.
Xhaka hit an attempted clearance straight at Chris Wood in the early kick-off at Turf Moor, ultimately costing Mikel Arteta's side a point.
Ralph Hasenhuttl's team then dispatched lowly Sheffield United 2-0 to finally rediscover some form, with Aston Villa and Wolves later playing out a goalless draw.
Leicester City beat Brighton and Hove Albion 2-1 in the late kick-off, and we took a look at the best Opta facts from Saturday's action.
Burnley 1-1 Arsenal: X-rated error costs Arteta
Arsenal could have closed the gap between themselves and Tottenham to just two points ahead of next week's north London derby, yet had to settle for a point against Burnley, who have now won just one game in 10 in all competitions.
The Gunners took the lead through Pierre-Emerick Aubameyang in the sixth minute. Arsenal's captain has scored more Premier League goals against Burnley (eight) than against any other club, while he only has a better record against Hamburg (nine) in Europe's 'top five' leagues.
However, they were hindered by Xhaka's error. The midfielder attempted to play his way out of a tight spot in Arsenal's area, only for his clearance to strike Chris Wood and bobble in.
Since the start of 2016-17, Xhaka has made eight errors leading to goals in the top flight, which is more than any other outfield Premier League player.
Arsenal have now kept only one clean sheet in their past 11 games in all competitions (0-0 v Manchester United in January), after keeping five in a row directly before that.
Burnley, on the other hand, have drawn five consecutive home league games for the third time in their history, after a run of six games ending in April 1936 and a run of five ending in October 1997.
Sheffield United 0-2 Southampton: Adams blunts his former club as Saints buck the trend
Che Adams scored a stunning goal to condemn his former team Sheffield United to another defeat, while simultaneously helping Southampton end their dismal run of form.
Southampton had lost eight of their past nine league matches heading into Saturday's meeting at Bramall Lane, having not won since beating Liverpool on January 4.
Captain James Ward-Prowse opened the scoring from the penalty spot; he has been directly involved in 26 Premier League goals under Hasenhuttl (18 goals, eight assists), twice as many as under any other Southampton manager.
It also moved Ward-Prowse onto seven goals in all competitions, his joint-best return in a single campaign. Six of these seven goals have come from dead ball situations (five direct free-kicks, one penalty).
Southampton had been hit by an early injury to Danny Ings, yet his replacement Adams stepped up, slamming in a spectacular half-volley to make it 2-0 shortly after half-time.
Adams has scored four goals in his four Premier League appearances against the Blades, accounting for 44 per cent of his total goals in the competition, while Chris Wilder's men have become only the second English top-flight team to lose 22 of their first 28 games in a season after Sunderland in 2005-06.
Aston Villa 0-0 Wolves: Grealish absence continues to hit home
There was no winner in Saturday's local derby as Wolves extended their unbeaten run in the Premier League at Villa Park to five matches (W2 D3).
Villa have failed to score in each of their past four home Premier League games against Wolves – only against Chelsea (a run of five between October 1995 and January 2000) and Manchester United (a run of five between March 2003 and December 2006) have they had a longer run of games without scoring against a specific opponent at Villa Park in the competition.
Jack Grealish was again absent through injury and, under Dean Smith, Villa have won just two of their 12 home league games without the playmaker (D5 L5).
On the plus side for Villa, they have kept 14 clean sheets in the Premier League this season, their highest tally in a single top-flight campaign since 2009-10 (15), with only Manchester City (15) having kept more this term.
Wolves, meanwhile, have won just one of their past 10 away Premier League games (D4 L5), with that victory coming at Southampton in February.
Brighton and Hove Albion 1-2 Leicester City: Amartey late show gets Foxes back on track
Daniel Amartey proved the unlikely hero for Leicester as they got back on track in their bid to consolidate their place in the top four with a last-gasp 2-1 win over Brighton.
Graham Potter's side took the lead through Adam Lallana's maiden Brighton goal, and his first in 503 days and 32 appearances in the competition since netting for Liverpool against Manchester United in October 2019.
However, Brighton have now dropped 17 points from winning positions in the Premier League this season, their most in a single campaign in the competition. Only Southampton (18) have dropped more than the Seagulls in 2020-21.
Kelechi Iheanacho restored parity and has scored in each of his past two Premier League appearances, having netted in just one of his previous 17 in the competition.
Brighton thought they might come away with a point when Jamie Vardy had a penalty appeal turned down, but Amartey popped up with the winner from the following corner.
It was just his second Premier League goal, and his first since he scored against Stoke City in December 2016.