Paul Pogba lasted only 39 minutes on his return to the Manchester United starting line-up against Everton on Saturday.
World Cup winner Pogba, who has rediscovered something approaching his best form in recent months, was left on the bench for the midweek 9-0 rout of Southampton at Old Trafford.
The France international replaced Fred against Everton in the only change to that side, yet it ended up being merely a temporary switch.
Fred was called from the bench shortly before half-time when Pogba pulled up immediately after playing a simple pass, seemingly indicating an issue with his thigh.
The midfielder was helped off the pitch and headed for treatment, dealing a blow to Ole Gunnar Solskjaer in his 100th match as a Premier League manager.