Agha Salman, Abdullah Shafique and Kamran Ghulam have been omitted from Pakistan's squad for the first Test against South Africa.
The trio were named in an initial squad of 20 for the opening Test in Karachi, which starts on Tuesday, but did not make the final cut.
With Shafique overlooked, Imran Butt looks set to be handed his debut his debut at the top of the order.
Pakistan were whitewashed 2-0 in their last Test series against New Zealand and are without a win in five matches in the longest format, but head coach Misbah-ul-Haq is optimistic they can turn the tide.
He said: "Understanding how poor we were in the field on our previous New Zealand tour, we have given fielding much importance while preparing [to play the Proteas].
"We are having extraordinary training sessions, with dedicated sessions to bring improvements. We are overall ready and looking forward to taking on South Africa."
Pakistan squad: Abid Ali , Imran Butt, Azhar Ali, Babar Azam (captain), Fawad Alam, Saud Shakeel, Faheem Ashraf, Mohammad Nawaz, Mohammad Rizwan, Sarfraz Ahmed, Nauman Ali, Sajid Khan, Yasir Shah, Haris Rauf, Hasan Ali, Shaheen Shah Afridi, Tabish Khan.