Steve Nash admitted the Brooklyn Nets were "a little lost at times" during Wednesday's defeat to the Cleveland Cavaliers.

The Nets' 'Big Three' of Kevin Durant, James Harden and Kyrie Irving played together for the first time, but Brooklyn fell to the Cavs 147-135 after double overtime.

Durant (38 points and 12 rebounds), Irving (37 points) and Harden (21 points, 12 assists and 10 rebounds) combined for 96 points, yet Collin Sexton (42 points) inspired the Cavs.

Nets head coach Nash said it was normal to see his new-look team struggle at times.

"This is the first night that we've had everyone on the floor together. We seemed a little lost at times, which is natural because we haven't played together so there's a little indecision," he told a news conference.

"We started the game turning the ball over, I think we had seven or eight in the first quarter. We cleaned it up, got ourselves back in the game. Obviously, we have to defend better, but I stay positive.

"These guys, it's the first night out together, we're just getting a feel for each other and this is going to be a process that's going to take the entire year. While we're all disappointed, we've got lots to build on, lots to grow and lots more opportunities."

The Nets gave up 20 points in the second period of overtime to lose the game.

Nash said the defense would be a key focus for Brooklyn (9-7) as the season goes on.

"We had breakdowns all over the place. We've got a lot of work to do, we know that," he said.

"We know that we have a very offensive team right now so we have to find ways to defend, to get connected, to be on the same page and that's going to take some time.

"It's definitely early doors as far as this new team, this new group, [are] learning to defend together and how we can be effective defensively, and that's got to be the part of our game that we're going to focus on the most going forward."

The Nets face the Cavs again on Friday.