Jurgen Klopp says Liverpool's fond memories of travelling to Porto will count for nothing when the two sides meet at Estadio do Dragao on Tuesday.
The Reds cruised to a 4-1 victory in their last trip to Porto almost two and a half years ago, having thrashed them 5-0 in their previous visit in February 2018 - Sadio Mane scoring a hat-trick.
Liverpool head into their second Champions League match of the season top of Group B after beating Milan 3-2 in a thriller at Anfield.
Porto held Atletico Madrid to a goalless draw and Sergio Conceicao's side are unbeaten since losing the first leg of their Champions League quarter-final to eventual winners Chelsea in April.
Klopp, who will welcome Naby Keita back from a foot injury, dismissed the suggestion the Reds' past two visits to Porto can stand them in good stead to secure another three points.
The Liverpool boss said: "Porto have had players coming out and in but have the same manager. It's not an advantage to have won the last two games there.
"We think about this game and they have different opportunities to set up and we have to prepare for that."
He added: "We don't count on points we don't have already, it's a tough group so we should not waste time to get points.
"Atletico versus Porto was a tough one and if someone deserved to win it, it was Porto, so that says a lot. The team we face tomorrow."
Liverpool were held to a 3-3 draw with Brentford in a pulsating Premier League clash on Saturday and Klopp expects a response at Porto.
"I don't think it's that much of a concern but we do have to show reaction that's for sure," he said of dropping points against the Bees.
"It's tricky to win a football game when you are not defending on your highest level and that is what we didn't do.
"Porto is a different team and will play a different style but we will go direct as well and go for second balls so yeah we have to improve in that department for sure."
Klopp will not be able to call upon Spain midfielder Thiago Alcantara, who remains sidelined due to a thigh injury.
Porto have failed to beat the Merseyside club in eight attempts, losing five and drawing three.