There was little threat of any major upsets in Rome on Friday, with Rafael Nadal and Novak Djokovic booking their places in the last eight.
A first match in more than 10 years against fellow Serbian Filip Krajinovic was not easy, conceded Novak Djokovic.
Karolina Pliskova and Simona Halep avoided upsets at the Internazionali d'Italia, as Garbine Muguruza swept Johanna Konta aside.
It was a day to forget at the Internazionali d'Italia for Australian Open champion Sofia Kenin, as she lost without winning a game.
After winning the US Open, Naomi Osaka is out of the French Open due to injury.
The French Open has reduced the number of fans allowed daily at the tournament from 11,500 to 5,000.
Fabio Fognini paid for a sloppy performance as he crashed out of the Internazionali d'Italia. Andrey Rublev and Milos Raonic also departed.
Aside from a defeat for Belinda Bencic, it was a good day for the seeds in Rome, with Simona Halep among the winners.
Jannik Sinner stunned Stefanos Tsitsipas, but there was no drama for Novak Djokovic or Rafael Nadal in Rome.
Salvatore Caruso proved no match for Novak Djokovic at the Internazionali d'Italia, as the world number one returned to action in style.
There was a lengthy rain delay during Garbine Muguruza's match with Sloane Stephens, but the Spaniard adapted and overcame.
Naomi Osaka's first grand slam title proved far less enjoyable than she would have expected, but her second US Open triumph was a thrill.
Trailing by a set and a break, Naomi Osaka wanted to avoid a thrashing in the US Open final.
Naomi Osaka showed exceptional fight to triumph at the US Open again, two years after her first victory was overshadowed.
Jet lag could not hold back Elena Rybakina as she gained revenge over Ekaterina Alexandrova in Rome on Monday.
Yannick Hanfmann proved no match for Miomir Kecmanovic in Kitzbuhel on Sunday, as the world number 47 sealed his maiden tour-level title.
Rafael Nadal preached the importance of self-control after being asked about Novak Djokovic's stunning US Open default.
Lorenzo Musetti was three when Stan Wawrinka made his Internazionali d'Italia debut but the home hope downed the three-time grand slam king.