Having set her sights on the Stuttgart Open title, Simona Halep made a strong start to her clay-court season against Marketa Vondrousova.
Normal service was resumed for Rafael Nadal after Kei Nishikori took the second set off the top seed in Barcelona.
Former world number six Carla Suarez Navarro announced "I'M CURED" after a cancer battle, and she is set to return to professional tennis.
It was a comfortable debut at the Stuttgart Open for Ash Barty, though it was a trickier outing for Petra Kvitova.
Rafael Nadal toiled in Barcelona but Novak Djokovic was in fine form at the Serbia Open on Wednesday.
US athletes, teams and leagues reacted after a jury found a former police officer guilty in the murder of George Floyd.
Jannik Sinner has won his previous two matches against Roberto Bautista Agut, and now he will target a third success, on clay in Barcelona.
Petra Kvitova and Aryna Sabalenka were first-round winners on Stuttgart on Tuesday, while Fiona Ferro caused a shock in Istanbul.
Japanese star Kei Nishikori emerged from the jaws of defeat to progress at the Barcelona Open on Monday.
With victory in Stuttgart, Belinda Bencic took a step towards getting her "love affair with clay" back on track.
Stefanos Tsitsipas called it the best week of his tennis life after he capped his Monte Carlo Masters run with victory in Sunday's final.
The legendary Roger Federer will be back in action on home soil in Geneva next month before playing at Roland Garros.