Stefanos Tsitsipas and Andrey Rublev reached the last 16, however, in-form seed Aslan Karatsev farewelled Miami.
Greek star Stefanos Tsitsipas and Kei Nishikori will meet in the third round of the Miami Open.
Stefanos Tsitsipas eased past John Isner, Alexander Zverev beat Laslo Djere and Lorenzo Musetti stunned Frances Tiafoe.
Emerging 19-year-old Lorenzo Musetti stunned world number nine Diego Schwartzman in Mexico.
World number one Novak Djokovic claimed grand slam win number 300, prevailing in four sets against Milos Raonic despite injury concerns.
Novak Djokovic will not train on Saturday as planned, the injured champion leaving his Australian Open fate in the hands of doctors.
Novak Djokovic and Dominic Thiem are both through to the last 16, but the Austrian looked to be in better shape after his triumph.
He found a way to prevail against Taylor Fritz, but Novak Djokovic does not know if he will be fit to face Milos Raonic.
Novak Djokovic said he had "no respect" for Nick Kyrgios and refused to reply to the Australian's response after winning at Melbourne Park.
Pablo Carreno Busta's hopes of beating Diego Schwartzman to the last ATP Finals qualifying spot were ended by Rafael Nadal in Paris.