Tottenham could only draw 2-2 with Everton at Goodison Park, meaning they may fall further behind the top four this weekend.
Manchester City and Everton players feature prominently in our Opta-powered Fantasy Picks ahead of this weekend's Premier League action.
Liverpool's dismal run continued as they surrended their Merseyside dominance, while Thomas Tuchel's Chelsea were held by Southampton.
Everton claimed their first win at Anfield since 1999 thanks to Richarlison and Gylfi Sigurdsson as Liverpool slipped to another defeat.
Both Manchester sides set club records on Saturday, but City will certainly be happier than Ole Gunnar Solskjaer's goal-shy United.
Southampton striker Danny Ings is joined by Wilfried Zaha and Harvey Barnes in our Opta-powered fantasy picks.
Gylfi Sigurdsson converted from the spot to punish a rash Edouard Mendy challenge as Everton toppled Chelsea on Merseyside.
Peter Gulacsi was let off the hook for a dreadful error as Dominik Szoboszlai's stoppage-time strike completed a stunning turnaround.
Watford face a daunting trip to Anfield as Arsenal host Manchester City - kick-start the Premier League weekend with our Opta-powered quiz.
Everton need a change of fortunes in the Premier League, which means they could arguably do without a trip to in-form Leicester City.