Toni Kroos has been diagnosed with a muscle issue after coming off during the first half of Real Madrid's win over Real Betis.
Germany head coach Joachim Low bemoaned his side's inability to keep possession and take chances after their 1-1 draw with Switzerland.
Silvan Widmer's equaliser left Germany still waiting for a win in the Nations League as they were held by Switzerland at St-Jakob Park.
Joachim Low would have preferred to see Kai Havertz stay in Germany, but he also knows his move to Chelsea can bring positives.
Thiago Alcantara has been widely tipped to sign for Liverpool but insists he has never said he wants to leave Bayern Munich.
Chelsea are closing in on the signing of Kai Havertz, who left Germany's camp in Stuttgart on Friday.
Joachim Low does not intend to reverse his decision to freeze Thomas Muller out of the Germany set-up despite his brilliant 2019-20 season.
Jose Gaya snatched a last-gasp equaliser for Spain against Germany but the 1-1 draw would not have been possible without David de Gea.
Timo Werner and Joachim Low discussed Germany's draw at home to Spain in Stuttgart on Thursday.
Bayern Munich's Thiago Alcantara has been widely tipped to sign for Liverpool but the Spain star has hinted he may remain in Germany.