Leeds Rhinos hammered Hull KR but Harry Newman suffered a season-ending injury, while there were wins for Huddersfield Giants and Salford.
Leeds Rhinos had to stand down seven players due to COVID-19 concerns on Friday but still came up with a win against Huddersfield Giants.
Greg Minikin scored a hat-trick as Hull KR stunned Super League leaders Wigan Warriors at Headingley.
Hull FC had 12 cases of coronavirus at the club in mid-August, but they returned to action with a handsome win on Sunday.
Castleford Tigers forged a 14-point lead but an Israel Folau-inspired Catalans Dragons ran out 40-14 winners.
Mose Masoe was making great progress with his recovery when he was told he must return home due to the coronavirus crisis.
There was no date specified over a potential Super League return following a meeting between clubs and RFL officials.
Wigan Warriors sit two points clear in Super League after they overcame Hull KR at the DW Stadium on Sunday.
Ryan Brierley's sin-binning ultimately proved costly as Hull KR succumbed to defeat at home to Castleford Tigers.
Castleford Tigers beat Wakefield Trinity for a 14th straight time, as Huddersfield Giants and Warrington Wolves also claimed wins.