Wales back George North said "heartbroken is an understatement" after knee ligament damage ruled him out of the Lions tour.
England will be out to put a dent in Wales' Six Nations title hopes in Cardiff and enhance their own chances of retaining the trophy.
George North akan menjadi pemain termuda dalam dunia ragbi mencecah penampilan antarabangsa ke-100 selepas Wales menamakannya dalam barisan utama perlawanan menentang England dalam Kejohanan Ragbi Enam Negara esok.
Wales will be out to make it three wins from three in the 2021 Six Nations when they face England on a milestone occasion for George North.
The Ospreys were on the verge of victory despite George North's early red card, but Ashton Hewitt's try salvaged a draw for the Dragons.
Josh Navidi is set to miss the majority of the Six Nations, while George North shifts to centre for Wales' first match of the tournament.
Ospreys were boosted by George North's return but still could not see off Dragons in Pro14.
Wales have received a boost for their quarter-final with France after Dan Biggar, Jonathan Davies and George North were all passed fit.
Gareth Davies put in an inspired first-half display as Wales got their Rugby World Cup up and running with a 43-14 triumph over Georgia.
The Ospreys have confirmed Alun Wyn Jones and George North both sustained injuries during the Six Nations that could end their season.