Inter finished bottom of Champions League Group B after failing to take their chances, while Shakhtar Donetsk claimed a Europa League spot.
Real Madrid have a tough test against Borussia Monchengladbach between them and a place in the last 16 of the Champions League.
Real Madrid have struggled in Karim Benzema's absence but the experienced striker is back to face Shakhtar Donetsk in the Champions League.
Antonio Conte and Inter are in desperate need of a Champions League victory as matchday five gets underway.
Real Madrid boss Zinedine Zidane believes Eden Hazard will return stronger following his latest injury setback.
Shakhtar Donetsk shocked Real Madrid last month, and Tete believes their win may have contributed to in-house issues for Los Blancos.
Inter played as a "real team" in their second consecutive Champions League draw, according to boss Antonio Conte.
Romelu Lukaku was unable to add to his scoring streak as Inter, who twice hit the crossbar, were held by Shakhtar Donetsk.
Romelu Lukaku and Lautaro Martinez have room for improvement despite their spectacular Inter form, Antonio Conte says.
Lautaro Martinez was asked about his future on the eve of Inter's Champions League fixture at Shakhtar Donetsk.