South Africa were skittled for 89 by Australia at the Wanderers, as leg-spinner Ashton Agar took five wickets including a hat-trick.
Ashton Agar claimed career-best Twenty20 international figures, including a hat-trick, as Australia won handsomely in Johannesburg.
David Warner was embroiled in controversy in Australia's last tour of South Africa, but he is not expecting tensions to boil over this time.
Steve Smith says he has been given a warm welcome in South Africa, but is expecting hostility when he faces the Proteas.
South Africa must cope without injured opener Temba Bavuma for the first Twenty20 clash of their three-match series against Australia.
Despite quitting as captain on Monday, Faf du Plessis returns to the South Africa squad for the upcoming T20 series with Australia.
After a period of reflection, Faf du Plessis has stepped down as South Africa captain in all formats.
Captain Eoin Morgan says victory over South Africa in a run-fest should be a "reference point" for England.
Captain Eoin Morgan blasted seven sixes as England completed a T20 series turnaround by winning a thriller in the decider.
The 20th annual Laureus World Sports Awards will take place on Monday in Berlin, with Lionel Messi and Liverpool in the hunt.