England pair Ross Barkley and Tom Heaton will miss the upcoming Euro 2020 qualifiers.
Liverpool host Manchester City as Leicester City face Arsenal, but Frank Lampard and Chelsea are focused on winning their own fixture.
After it was reported Antonio Rudiger had declared himself fit, Chelsea boss Frank Lampard insisted that was not the case.
Ross Barkley, N'Golo Kante and Antonio Rudiger have not travelled with Chelsea for Wednesday's trip to Ajax.
Ross Barkley went off in the first half of Chelsea's win over Newcastle United, leaving Frank Lampard a little concerned.
Ross Barkley was filmed arguing with a taxi driver on Sunday and the Chelsea midfielder has admitted to making a mistake.
Jorginho is Chelsea's primary penalty taker following Ross Barkley's miss against Valencia earlier this month, boss Frank Lampard confirmed.
Chelsea cruised into the fourth round of the EFL Cup with a 7-1 win over League Two side Grimsby Town at Stamford Bridge on Wednesday.
There was no doubt about Chelsea's penalty taker before Ross Barkley's miss against Valencia, according to the midfielder.
Ross Barkley insisted he was feeling confident before missing Chelsea's second-half penalty against Valencia, according to Willian.