New York City and Sporting Kansas City won through to the last eight of the tournament at Walt Disney Resort on Sunday.
A draw was enough for Orlando City to win their group ahead of Philadelphia Union on Monday.
Ill discipline was evident for Inter Miami again as they were beaten 1-0 by New York City to extend their winless start.
Inter Miami's struggles continued, beaten by Philadelphia Union at the MLS is Back Tournament.
New York City are enduring their worst start to an MLS season after losing their Group A meeting with Philadelphia Union on Thursday.
A clash between Orlando City and Inter Miami will get the MLS season back underway.
Harry Kane to Manchester United? Ed Woodward is reportedly ready to try to prise the striker to Old Trafford.
Inter Miami slumped to a second straight loss to start the MLS season, beaten by DC United.
LaLiga champions Barcelona are reportedly making their move for Inter's Lautaro Martinez.
Inter Miami made their debut on Sunday but the league's expansion franchise left Los Angeles emptyhanded.