Scrum-half Kieran Hardy has been released from the Wales Six Nations squad, while Dan Biggar also has an injury problem.
Aaron Smith has recommitted to the All Blacks, Highlanders and Manawatu ahead of the Rugby World Cup and some major career milestones.
Wales coach Wayne Pivac had little sympathy for England after his side benefitted from some contentious officiating in Saturday's clash.
Pascal Gauzere awarded two controversial first-half tries for Wales before England were punished for poor discipline in Cardiff.
England will be out to put a dent in Wales' Six Nations title hopes in Cardiff and enhance their own chances of retaining the trophy.
Wales will be out to make it three wins from three in the 2021 Six Nations when they face England on a milestone occasion for George North.
Just a day after receiving the green light for the game to go ahead, France's clash with Scotland has been postponed.
There have been no more positive COVID-19 tests in the France squad over the past two days, so they are set to take on Scotland in Paris.
With 14 confirmed coronavirus positives, France's Six Nations match with Scotland on Sunday may well be postponed.
Six Nations leaders France are up to nine coronavirus positives, with Julien Marchand and Arthur Vincent ruled out of facing Scotland.