Jack Willis suffered serious knee ligament damage in England's loss to Italy and is facing a year on the sidelines.
Ireland and Leinster will continue to enjoy the services of Johnny Sexton after the fly-half agreed an IRFU contract extension.
Maro Itoje received backing from Eddie Jones after England's loss to Wales, while Ellis Genge has received death threats on social media.
Pascal Gauzere awarded Wales two controversial first-half tries, but Eddie Jones and Owen Farrell did not vent their fury at the referee.
Wales coach Wayne Pivac had little sympathy for England after his side benefitted from some contentious officiating in Saturday's clash.
Pascal Gauzere awarded two controversial first-half tries for Wales before England were punished for poor discipline in Cardiff.
Wales sealed a triple crown as Wayne Pivac's side saw off reigning Six Nations champions England in an action-packed encounter on Saturday.
Ireland hammered Italy in the Six Nations in Rome and Johnny Sexton feels the team are showing signs of improvement.
Johnny Sexton returned to Ireland's team and led Andy Farrell's side to their first win of the 2021 Six Nations.
England will be out to put a dent in Wales' Six Nations title hopes in Cardiff and enhance their own chances of retaining the trophy.