A five-week break has been implemented in the Premiership, with the Champions Cup and Challenge Cup quarter-finals pushed back.
Exeter Chiefs have returned to the Premiership summit, while Wasps and Saracens also celebrated victories.
England overlook Mako Vunipola as a coronavirus precaution, yet he will play for Saracens against Leicester Tigers.
Nemani Nadolo will be in Leicester Tigers colours next season after the Premiership club lured the former Fiji powerhouse from Montpellier.
Marland Yarde was in fine form as Sale Sharks went second in the Premiership table in style against Leicester Tigers.
London Irish handled challenging conditions impressively to win at Harlequins, while champions Saracens were too good for Sale Sharks.
Exeter Chiefs rallied in the second half against Sale Sharks, but the Premiership leaders still slipped to a first defeat since November.
Leicester Tigers have moved Geordan Murphy to a director of rugby role, with Steve Borthwick joining as head coach.
Five tries in each half saw Premiership basement side Saracens make light work of thumping Worcester Warriors on Saturday.
Munster put in a monumental effort, but Leinster's defence refused to buckle at Thomond Park.