Ospreys were no match for Saracens on Saturday, while Exeter Chiefs were among the other European Champions Cup winners.
With Jonathan Davies already ruled out, Wales prop Tomas Francis is also set to miss much of the 2020 Six Nations campaign.
Ireland centre Garry Ringrose was the star of the show as Leinster started their bid to regain the Champions Cup with a bonus-point win.
Exeter Chiefs were in control at half-time, but Bristol Bears scored 20 points without reply in the second half to snatch a stunning win.
A fine of £5.36million fine and the deduction of 35 points will not necessitate a fire sale at Saracens, the club's chairman insists.
Having been the dominant force at home and abroad, Saracens' success is now facing significant scrutiny.
European Professional Club Rugby are not happy that Champions Cup holders Saracens were not represented at a launch event on Wednesday.
A late Harry Williams try proved decisive as Exeter Chiefs came from 14 points behind to overcome Worcester Warriors.
Exeter Chiefs fell to a narrow Premiership defeat at Bath, as Stuart Hogg's first appearance ended in disappointment.
Northampton Saints claimed a win over the reigning champions at Allianz Park on the opening weekend of the Premiership season.